This invention relates generally to methods and systems for removing an artifact within an image. Typically, the artifact is a guidewire artifact. In one aspect, at least two images of an imaging surface are acquired. Each acquired image comprises a set of data. A guidewire artifact is detected in one of the at least two images. The guidewire artifact is replaced with data representing the imaging surface obtained from another one of the at least two images. In certain embodiments, the at least two images are of the same imaging surface having a guidewire or object causing the artifact moved to a different position.