A control circuit for use with a four terminal sensor, such as a glucose sensor. The Glucose sensor is a volume product and typically its manufacture will want to make it as inexpensively as possible. This may give rise to variable impedances surrounding the active cell of the sensor. Typically the sensor has first and second drive terminals and first and second measurement terminals, so as to help overcome the impedance problem. The control circuit is arranged to drive at least one of the first and second drive terminals with an excitation signal, and control the excitation signal such that a voltage difference between the first and second measurement terminals is within a target range of voltages. To allow the control circuit to work with a variety of measurement cell types the control circuit further comprises voltage level shifters for adjusting a voltage at one or both of the drive terminals, or for adjusting a voltage received from one or both of the measurement terminals.