An integrated circuit for configuring and reconfiguring a configuration shift register (CSR) partial reconfiguration region is disclosed. The integrated circuit includes a CSR chain that is partitioned into a group of CSR partial reconfiguration regions. A multiplexer circuit is added to the end of each PR region to allow the PR region to be bypassed or connected to the next PR region. Each PR region is connected to a PR circuit that facilitates the CSR configuration of the respective PR region. The PR circuit includes region enable circuitry and region control circuitry. Region enable circuitry enables the configuration of the CSR PR region. Region control circuitry generates local reconfiguration control signals to control the configuration operation of the enabled CSR PR region.