Invention Grant
- Patent Title: Dengue virus vaccine compositions and methods of use thereof
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Application No.: US14898515Application Date: 2014-06-17
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Publication No.: US09861692B2Publication Date: 2018-01-09
- Inventor: Andrew Bett , Beth-Ann Griswold Coller , Govindarajan Dhanasekaran , Ramesh V. Chintala
- Applicant: Andrew Bett , Beth-Ann Griswold Coller , Govindarajan Dhanasekaran , Ramesh V. Chintala
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Letitia Walker; Gloria M. Fuentes
- International Application: PCT/US2014/042625 WO 20140617
- International Announcement: WO2014/204892 WO 20141224
- Main IPC: A61K39/12
- IPC: A61K39/12 ; A61K39/00 ; C12N7/00 ; C07K14/005 ; C12N15/86
Abstract:
The present invention relates to dengue virus vaccine compositions comprising a first and a second dengue vaccine, wherein the first dengue vaccine is a live, attenuated dengue vaccine and the second dengue vaccine is a recombinant dengue subunit vaccine or an inactivated dengue vaccine; wherein the live attenuated dengue vaccine comprises at least one live, attenuated dengue virus or at least one live attenuated chimeric flavivirus. The dengue virus vaccine compositions of the invention may further comprise one or more adjuvants. In preferred embodiments of the invention, the first and the second dengue vaccine are tetravalent. The invention also relates to methods of using the dengue virus vaccine compositions of the invention to treat or prevent dengue infection, or to prevent, ameliorate, or delay the onset or progression of the clinical manifestations thereof.
Public/Granted literature
- US20160151477A1 DENGUE VIRUS VACCINE COMPOSITIONS AND METHODS OF USE THEREOF Public/Granted day:2016-06-02
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