Invention Grant
- Patent Title: PSMA-binding agents and uses thereof
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Application No.: US14987032Application Date: 2016-01-04
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Publication No.: US09861713B2Publication Date: 2018-01-09
- Inventor: Martin G. Pomper , Ronnie Charles Mease , Ying Chen
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Michael Best & Friedrich, LLP
- Agent Jeffrey W. Childers
- Main IPC: A61K51/00
- IPC: A61K51/00 ; A61K51/04 ; A61K9/127 ; C07C275/16 ; C07D213/61 ; C07D213/74 ; C07D213/82 ; C07F7/22 ; C07C275/18
Abstract:
Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
Public/Granted literature
- US20160114060A1 PSMA-BINDING AGENTS AND USES THEREOF Public/Granted day:2016-04-28
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