A catheter adapter assembly includes an adapter body and a slider body. The adapter body includes a distal end portion configured to receive a catheter, a coupling disposed on the distal end portion, and a fitting on the proximal end portion. The slider body is disposed about the adapter body and axially slides along the adapter body. The slider body includes a release, a latch disposed at a distal end of the release, and a flexing portion disposed at a proximal end of the release. The slider body also includes compression element that compresses the tubular catheter receiver in response engagement of the latch and the coupling. A catheter adapter system comprising the catheter adapter assembly and a nest that holds the catheter adapter assembly is also disclosed.