A hand anti-cutting structure for a curtain cutting machine contains a base, a cutting mechanism, and a security mechanism. The cutting mechanism includes a through orifice, an insertion segment, an extension segment, an inserting direction, and a cutter. The security mechanism includes a rail assembly, a sliding seat, a touch switch, and a stop member. The rail assembly has at least slidable rail parallel to the inserting direction, and the sliding seat has a movable actuation member and an operation member. The touch switch is secured on a moving path of the actuation member, and when the actuation member moves to abut against the touch switch, the touch switch is turned on by the actuation member. The stop member is connected with and driven by the actuation member, wherein the stop member is located on the insertion segment and is perpendicular to the inserting direction of the cutting mechanism.