Invention Grant
- Patent Title: Method for in-vitro preparation of double-layered virus-like particles of rotavirus
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Application No.: US14429586Application Date: 2013-06-24
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Publication No.: US09862933B2Publication Date: 2018-01-09
- Inventor: Shengxiang Ge , Tingdong Li , Qingshun Guo , Feihai Xu , Jun Zhang , Ningshao Xia
- Applicant: Xiamen University , Xiamen Innovax Biotech Co., Ltd.
- Applicant Address: CN Xiamen, Fujian CN Xiamen, Fujian
- Assignee: Xiamen University,Xiamen Innovax Biotech Co., Ltd.
- Current Assignee: Xiamen University,Xiamen Innovax Biotech Co., Ltd.
- Current Assignee Address: CN Xiamen, Fujian CN Xiamen, Fujian
- Agency: Honigman Miller Schwartz and Cohn LLP
- Agent Thomas A. Wootton, Esq.; Jonathan P. O'Obrien
- Priority: CN201210350365 20120920
- International Application: PCT/CN2013/077736 WO 20130624
- International Announcement: WO2014/044067 WO 20140327
- Main IPC: C12N7/04
- IPC: C12N7/04 ; C12N7/00 ; A61K38/16 ; A61K39/00
Abstract:
The invention relates to a method for preparing double-layered virus-like particles of rotavirus in vitro. The method comprises the following steps: purifying rotavirus VP6 proteins from a lysis supernatant, and in vitro assembling double-layered virus-like particles consisting of VP2 proteins and VP6 proteins, wherein the proteins and the virus-like particles can be used for preventing or reducing the clinical symptoms caused by rotavirus infection.
Public/Granted literature
- US20150252334A1 Method for In-Vitro Preparation of Double-Layered Virus-Like Particles of Rotavirus Public/Granted day:2015-09-10
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