Invention Grant
- Patent Title: Method for the inhibition of angiogenesis
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Application No.: US15040487Application Date: 2016-02-10
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Publication No.: US09862949B2Publication Date: 2018-01-09
- Inventor: Stefanie Dimmeler , Andreas M. Zeiher , Angelika Bonauer , Carmen Urbich
- Applicant: t2cure GmbH
- Applicant Address: DE Frankfurt am Main
- Assignee: T2CURE GMBH
- Current Assignee: T2CURE GMBH
- Current Assignee Address: DE Frankfurt am Main
- Agency: Saliwanchik, Lloyd & Eisenschenk
- Priority: DE102007052114 20071030
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12Q1/68 ; C12N15/113 ; A61K31/7088 ; C07H21/02

Abstract:
The invention relates to a method for influencing the miR-92 expression in a cell, comprising the following steps: (a) providing a cell; and (b1) reducing the miR-92 expression in the cell in order to promote the vascularization or vessel repair by introducing an antisense molecule against miR-92 into the cell, or (b2) increasing the miR-92 expression in the cell for an inhibition of the tumor angiogenesis by introducing a construct into the cell, wherein said construct includes an expressible miR-92 sequence. Furthermore, the invention relates to a pharmaceutical composition, comprising an agent for reducing the miR-92 activity or expression in a cell in the form of an antisense molecule against miR-92, or an agent for increasing the miR-92 expression in a cell in the form of a construct for expressing miR-92.
Public/Granted literature
- US20160237433A1 METHOD FOR PROMOTING ANGIOGENESIS, VASCULARIZATION OR VESSEL REPAIR OR FOR INHIBITING TUMOR ANGIOGENESIS Public/Granted day:2016-08-18
Information query
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