Invention Grant
- Patent Title: Marker for prenatal diagnosis and monitoring
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Application No.: US15012611Application Date: 2016-02-01
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Publication No.: US09862999B2Publication Date: 2018-01-09
- Inventor: Yuk Ming Dennis Lo , Wai Kwun Rossa Chiu , Stephen Siu-Chung Chim , Yu-Kwan Tong , Chunming Ding
- Applicant: The Chinese University of Hong Kong
- Applicant Address: CN Shatin, N.T.
- Assignee: The Chinese University of Hong Kong
- Current Assignee: The Chinese University of Hong Kong
- Current Assignee Address: CN Shatin, N.T.
- Agency: Kilpatrick Townsend & Stockton LLP
- Main IPC: C07H21/04
- IPC: C07H21/04 ; C12Q1/68
Abstract:
The present invention relates to new methods for diagnosing a pregnancy-associated disorder by analyzing fetal DNA present in the mother's blood. More specifically, this invention relies on the discovery that the maspin gene is differentially methylated in fetal DNA and in maternal DNA and provides these new diagnostic methods, which distinguish fetal DNA from maternal DNA and detect prenatal disorders based on abnormalities in fetal DNA level and methylation status.
Public/Granted literature
- US20160258018A1 MARKER FOR PRENATAL DIAGNOSIS AND MONITORING Public/Granted day:2016-09-08
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