Systems and methods are provided for performing write-with-response operations in a network on a chip architecture. In response to receiving an instruction to perform a write-with-response operation, a writer computing resource of a computing system (implemented using the network on a chip architecture) executes this instruction by performing a write operation for writing data to a memory location followed by a response operation for notifying a notification target computing resource of the computing system that the data has been written to the memory location.