A method, system and computer program product are provided for implementing cable failover in multiple cable Peripheral Component Interconnect Express (PCIE) IO interconnections to an external IO enclosure. System firmware is provided for implementing health check functions for the PCIE IO interconnections to identify a faulted low byte cable. A cable failover mechanism recovers a PCI link to the external IO enclosure. A multiplexer logic is provided between the PCIE host bridge (PHB) and the cable connected to the IO enclosure to perform a full lane reversal of the PCIE lanes.