The invention relates to communication between computers such as servers within a content distribution network, where the communication is carried over the Internet in which bandwidth usage and cost are of concern, and particularly to a system and method for optimizing inter-node communication in a content distribution network. The method includes: generating a mutable warm dictionary for a specific domain according to a current inter-node communication; generating a fixed warm dictionary for the specific domain from the mutable warm dictionary; and performing the next inter-node communication for the specific domain according to the fixed warm dictionary.