Invention Grant
- Patent Title: Tetrahydroisoquinoline derivatives useful as inhibitors of diacylglyceride O-acyltransferase 2
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Application No.: US15508557Application Date: 2015-08-31
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Publication No.: US09877957B2Publication Date: 2018-01-30
- Inventor: Jason Imbriglio , Clare London , Zhijian Lu , James Tata , Yusheng Xiong , Ming You , Hyewon Youm
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Sarah Hooson; Catherine D. Fitch
- International Application: PCT/US2015/047655 WO 20150831
- International Announcement: WO2016/036636 WO 20160310
- Main IPC: C07D217/06
- IPC: C07D217/06 ; A61K31/47 ; C07C13/04 ; A61K31/16 ; C07D417/12
Abstract:
The present invention relates to a compound represented by formula I: and pharmaceutically acceptable salts thereof. The compounds of formula I are inhibitors of diacylglyceride O-acyltransferase 2 (“DGAT2”) and may be useful in the treatment, prevention and suppression of diseases mediated by DGAT2. The compounds of the present invention may be useful in the treatment of hepatic steatosis, diabetes mellitus, obesity, hyperlipidemia, hypercholesterolemia, atherosclerosis, cardio renal diseases such as chronic kidney diseases and heart failure and related diseases and conditions.
Public/Granted literature
- US20170273966A1 TETRAHYDROISOQUINOLINE DERIVATIVES USEFUL AS INHIBITORS OF DIACYLGLYCERIDE O-ACYLTRANSFERASE 2 Public/Granted day:2017-09-28
Information query
