Invention Grant
- Patent Title: Methods and compositions for enhancing the efficacy and specificity of single and double blunt-ended siRNA
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Application No.: US14271038Application Date: 2014-05-06
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Publication No.: US09879253B2Publication Date: 2018-01-30
- Inventor: Phillip D. Zamore , Dianne Schwarz
- Applicant: UNIVERSITY OF MASSACHUSETTS
- Applicant Address: US MA Boston
- Assignee: UNIVERSITY OF MASSACHUSETTS
- Current Assignee: UNIVERSITY OF MASSACHUSETTS
- Current Assignee Address: US MA Boston
- Agency: Lathrop Gage LLP
- Agent James H. Velema, Esq.
- Main IPC: C12N15/11
- IPC: C12N15/11 ; C12N15/113
Abstract:
The present invention provides methods of enhancing the efficacy and specificity of RNAi using single or double blunt-ended siRNA. The invention also provides single and double-blunt ended siRNA compositions, vectors, and transgenes containing the same for mediating silencing of a target gene. Therapeutic methods are also featured.
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