Systems and methods are disclosed for active cancellation of transmitter leakage in a radio receiver that reduce power consumption and/or reduce noise in a desired receive frequency band. In some embodiments, in order to cancel transmitter leakage in a receive path, a cancellation signal is injected into the receive path in an upstream direction. By injecting the cancellation signal in the upstream direction, a noise component of the cancellation signal propagates through the receive path in the upstream direction and is either passed through a receive antenna or attenuated by an upstream component. Conversely, a desired component of the cancellation signal is reflected by an upstream filter and, thereafter, propagates through the receive path in the downstream direction to thereby cancel the transmitter leakage in the receive path. In this manner, active transmitter leakage cancellation can be performed while minimizing degradation of receiver sensitivity.