Invention Grant
- Patent Title: Bile acid-basic amino acid conjugates and uses thereof
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Application No.: US14895723Application Date: 2014-06-05
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Publication No.: US09884066B2Publication Date: 2018-02-06
- Inventor: Oren Tirosh , Ira Voloshin , Shlomo Sasson , Michal Obercyger , Zecharia Madar
- Applicant: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
- Applicant Address: IL Jerusalem
- Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
- Current Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
- Current Assignee Address: IL Jerusalem
- Agency: Vorys, Sater, Seymour & Pease LLP
- International Application: PCT/IL2014/050505 WO 20140605
- International Announcement: WO2014/195950 WO 20141211
- Main IPC: A61K31/575
- IPC: A61K31/575 ; A61K31/573 ; C07J41/00 ; A61K47/48
Abstract:
Compositions and methods for treating diseases or disorders associated with the metabolic syndrome using conjugates of bile acids with basic amino acids or a decarboxylated amino acid such as agmatine are provided. Further provided are bile acid-basic amino acid conjugates including chenodeoxycholic acid with an amino acid selected from arginine, lysine, histidine, ornithine or a decarboxylated amino acid such as agmatine.
Public/Granted literature
- US20160120880A1 BILE ACID-BASIC AMINO ACID CONJUGATES AND USES THEREOF Public/Granted day:2016-05-05
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