Invention Grant
- Patent Title: Multicomponent degradable cationic polymers
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Application No.: US14644397Application Date: 2015-03-11
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Publication No.: US09884118B2Publication Date: 2018-02-06
- Inventor: Jordan J. Green , Joel C. Sunshine , Nupura S. Bhise , Ron B. Shmueli , Stephany Y. Tzeng
- Applicant: THE JOHNS HOPKINS UNIVERSITY
- Applicant Address: US MD Baltimore
- Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee: THE JOHNS HOPKINS UNIVERSITY
- Current Assignee Address: US MD Baltimore
- Agency: Morgan, Lewis & Bockius LLP
- Main IPC: A61K47/20
- IPC: A61K47/20 ; C08F222/10 ; A61K38/02 ; C07C323/25 ; A61K31/713 ; A61K9/107 ; C07C229/12 ; C08G73/02 ; C12N15/88 ; A61K48/00
Abstract:
Degradable polymers were synthesized that self-assemble with DNA to form particles that are effective for gene delivery. Small changes to polymer synthesis conditions, particle formulation conditions, and polymer structure provides significant changes to efficacy in a cell-type dependent manner. Polymers presented here are more effective than commercially available materials, such as LIPOFECTAMINE 2000™, FUGENE®, or polyethylenimine (PEI), for gene delivery to cancerous fibroblasts or human primary fibroblasts. The presently disclosed materials may be useful for cancer therapeutics and regenerative medicine.
Public/Granted literature
- US20150250881A1 Multicomponent Degradable Cationic Polymers Public/Granted day:2015-09-10
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