A device with a non-invasive first stimulation unit configured to generate first stimuli which, when administered to a patient, suppress a pathologically synchronous activity of neurons in at least one of the brain and the spinal cord of the patient, with a non-invasive second stimulation unit configured to generate at least one of optical, acoustic, tactile, vibratory, and thermal second stimuli, and with a control unit configured to control the first and second stimulation units, wherein the generation of the first and second stimuli takes place optionally in a first or a second operating mode, and the control unit is configured to control the first and second stimulation units in such a way that, in the first operating mode, the generation of at least 60% of the second stimuli is coupled in time to the generation of the first stimuli and, in the second operating mode, the generation of at least 60% of the second stimuli takes place without the generation of the first stimuli.