Invention Grant
- Patent Title: Neprilysin inhibitors
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Application No.: US15581327Application Date: 2017-04-28
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Publication No.: US09884807B2Publication Date: 2018-02-06
- Inventor: Melissa Fleury , Adam D. Hughes
- Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
- Applicant Address: US CA South San Francisco
- Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Wendy Petka
- Main IPC: C07D261/18
- IPC: C07D261/18 ; C07C229/22 ; C07D207/26 ; C07D231/14 ; C07D249/04 ; C07D253/08 ; C07D257/04 ; C07D263/38 ; C07D401/04 ; C07D405/12 ; C07D249/18 ; C07F9/6503 ; A61K31/675 ; A61K31/41 ; A61K31/4196 ; A61K31/42 ; A61K31/4439 ; A61K31/4155 ; A61K31/415 ; A61K45/06 ; A61K31/4192 ; C07D249/12 ; C07D405/14 ; C07D231/20 ; C07D231/18 ; C07C271/22

Abstract:
In one aspect, the invention relates to compounds having the formula XII: where Ra, Rb, R2, R7, and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. The compounds described herein are prodrugs of compounds having neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising these compounds; methods of using these compounds; and processes and intermediates for preparing these compounds.
Public/Granted literature
- US20170355664A1 NEPRILYSIN INHIBITORS Public/Granted day:2017-12-14
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