Invention Grant
- Patent Title: Acylguanidines for treating osteoarthritis
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Application No.: US14760765Application Date: 2013-12-16
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Publication No.: US09884814B2Publication Date: 2018-02-06
- Inventor: Christos Tsaklakidis , Markus Klein , Paul Czodrowski
- Applicant: Merck Patent GmbH
- Applicant Address: DE Darmstadt
- Assignee: MERCK PATENT GMBH
- Current Assignee: MERCK PATENT GMBH
- Current Assignee Address: DE Darmstadt
- Agency: Millen, White, Zelano & Branigan, P.C.
- Priority: EP13000180 20130115
- International Application: PCT/EP2013/003794 WO 20131216
- International Announcement: WO2014/111113 WO 20140724
- Main IPC: C07C279/22
- IPC: C07C279/22 ; C07D309/14 ; C07D317/58 ; C07D317/60 ; C07D333/20 ; C07D333/28 ; C07D233/61 ; C07D335/02 ; C07D249/08 ; C07D257/04 ; C07D271/06 ; C07D207/16 ; C07D271/113 ; C07D207/267 ; C07D207/273 ; C07D277/28 ; C07D209/48 ; C07D285/06 ; C07D211/58 ; C07D295/15 ; C07D213/40 ; C07D213/56 ; C07D213/61 ; C07D307/68 ; C07C311/46 ; A61K31/165 ; A61K31/18 ; A61K31/19 ; A61K31/216 ; A61K31/277 ; A61K31/341 ; A61K31/351 ; A61K31/36 ; A61K31/381 ; A61K31/382 ; A61K31/401 ; A61K31/4015 ; A61K31/4035 ; A61K31/41 ; A61K31/4164 ; A61K31/4196 ; A61K31/4245 ; A61K31/433 ; A61K31/44 ; A61K31/4402 ; A61K31/4409 ; A61K31/4468 ; A61K31/5375 ; C07C53/18 ; C07C277/08 ; C07D207/12 ; C07D211/98 ; C07D213/58 ; C07D231/12 ; C07D233/58 ; C07D271/10 ; C07D309/06 ; C07D323/02 ; C07D333/24
Abstract:
The present invention relates to compounds of the formula (I) and in particular to medicaments comprising at least one compound of the formula I for use in the treatment and/or prophylaxis of physiological and/or pathophysiological conditions in the triggering of which cathepsin D is involved, in particular for use in the treatment and/or prophylaxis of osteoarthritis, traumatic cartilage injuries, arthritis, pain, allodynia or hyperalgesia.
Public/Granted literature
- US20150361037A1 ACYLGUANIDINES FOR TREATING OSTEOARTHRITIS Public/Granted day:2015-12-17
Information query
