Invention Grant
- Patent Title: Auristatin derivatives and conjugates thereof
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Application No.: US15317532Application Date: 2015-06-11
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Publication No.: US09884817B2Publication Date: 2018-02-06
- Inventor: Bernhard Hubert Geierstanger , Jan Grunewald , Weijia Ou , Shifeng Pan , Tetsuo Uno , Yongqin Wan , Xing Wang
- Applicant: Bernhard Hubert Geierstanger , Jan Grunewald , Weijia Ou , Shifeng Pan , Tetsuo Uno , Yongqin Wan , Xing Wang
- Applicant Address: CH Basel
- Assignee: Novartis AG
- Current Assignee: Novartis AG
- Current Assignee Address: CH Basel
- Agency: Genomics Institute of the Novartis Research Foundation
- Agent Daniel E. Raymond
- International Application: PCT/IB2015/054400 WO 20150611
- International Announcement: WO2015/189791 WO 20151217
- Main IPC: C07D207/09
- IPC: C07D207/09 ; A61K47/48 ; C07D403/12 ; C07D401/12 ; C07D413/12 ; C07D403/14 ; C07K16/32

Abstract:
Disclosed herein are novel compounds of formula (I) as described herein: and the use of such peptides in making immunoconjugates (i.e Antibody Drug Conjugates) Also described herein are immunoconjugates (i.e Antibody Drug Conjugates) comprising such novel compound linked to an antigen binding moiety, such as an antibody; where such immunoconjugates are useful for treating cell proliferative disorders. The invention further provides pharmaceutical compositions comprising these immunoconjugates, compositions comprising the immunoconjugates with a therapeutic co-agent, and methods to use these immunoconjugates and compositions for treating cell proliferation disorders.
Public/Granted literature
- US20170121282A1 AURISTATIN DERIVATIVES AND CONJUGATES THEREOF Public/Granted day:2017-05-04
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