Invention Grant
- Patent Title: Chelates of lead (II) and bismuth (III) based on trans-di-N-picolinate tetraazacycloalkanes
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Application No.: US14895990Application Date: 2014-06-05
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Publication No.: US09884881B2Publication Date: 2018-02-06
- Inventor: Raphael Tripier , Carlos Platas-Iglesias , Luis Lima , Maryline Beyler
- Applicant: CNRS—CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE BRETAGNE OCCIDENTALE
- Applicant Address: FR Paris FR Brest
- Assignee: CNRS—Centre National de la Recherche Scientifique,Universite de Bretagne Occidentale
- Current Assignee: CNRS—Centre National de la Recherche Scientifique,Universite de Bretagne Occidentale
- Current Assignee Address: FR Paris FR Brest
- Agency: Thomas | Horstemeyer, LLP
- Priority: FR1355212 20130606
- International Application: PCT/EP2014/061723 WO 20140605
- International Announcement: WO2014/195416 WO 20141211
- Main IPC: C07F7/24
- IPC: C07F7/24 ; C07F9/94 ; C07D401/06 ; A61K51/04 ; C07K16/00 ; A61K47/68
Abstract:
The invention relates to a chelate resulting from the complexing of a trans-di-N-picolinate tetraazacycloalkane ligand with a metal cation, said ligand corresponding to formula (A) wherein n is equal to 0 or to 1, R is H or a C1-C18 alkyl radical, and R′ is H or a C1-C18 alkyl radical, said metal cation being a cation of a metal selected from the group consisting of lead (II) and bismuth (III). The invention is applicable in the field of lead trapping and alpha-radioimmunotherapy.
Public/Granted literature
- US20160115187A1 Chelates of Lead (II) and Bismuth (III) Based on Trans-Di-N-Picolinate Tetraazacycloalkanes Public/Granted day:2016-04-28
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