Invention Grant
- Patent Title: High affinity antibodies to human IL-6 receptor
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Application No.: US15136152Application Date: 2016-04-22
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Publication No.: US09884916B2Publication Date: 2018-02-06
- Inventor: Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Eric Smith , Kevin J. Pobursky , Nicholas J. Papadopoulos , James P. Fandl , Gang Chen , Margaret Karow
- Applicant: REGENERON PHARMACEUTICALS, INC.
- Applicant Address: US NY Tarrytown
- Assignee: REGENERON PHARMACUEUTICALS, INC.
- Current Assignee: REGENERON PHARMACUEUTICALS, INC.
- Current Assignee Address: US NY Tarrytown
- Agent Christopher Westberg; Frank Cottingham; Karl Bozicevic
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/00
Abstract:
A human antibody or an antigen-binding fragment which binds human IL-6 receptor (hIL-6R) with a KD of about 500 pM or less and blocks IL-6 activity with an IC50 of 200 pM or less, is provided. In preferred embodiments, the antibody the antibody or antigen-binding fragment binds hIL-6R with an affinity at least 2-fold higher relative to its binding monkey IL-6R.
Public/Granted literature
- US20160229916A1 HIGH AFFINITY ANTIBODIES TO HUMAN IL-6 RECEPTOR Public/Granted day:2016-08-11
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