Invention Grant
- Patent Title: Methods for treating apolipoprotein E4-associated disorders
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Application No.: US14668909Application Date: 2015-03-25
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Publication No.: US09885039B2Publication Date: 2018-02-06
- Inventor: Yadong Huang , Yaisa Andrews-Zwilling
- Applicant: THE J. DAVID GLADSTONE INSTITUTES
- Applicant Address: US CA San Francisco
- Assignee: The J. David Gladstone Institutes
- Current Assignee: The J. David Gladstone Institutes
- Current Assignee Address: US CA San Francisco
- Agency: Bozicevic, Field & Francis LLP
- Agent Michael B. Rubin
- Main IPC: A61K35/30
- IPC: A61K35/30 ; C12N5/0797 ; C12N15/113 ; A61K31/7088 ; A61K38/17
Abstract:
The present disclosure provides a method of increasing the functionality of a GABAergic interneuron in the hilus of the hippocampus of an individual having at least one apolipoprotein E4 (apoE4) allele. The method generally involves reducing tau levels in the interneuron.
Public/Granted literature
- US20150267198A1 METHODS FOR TREATING APOLIPOPROTEIN E4-ASSOCIATED DISORDERS Public/Granted day:2015-09-24
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