An illuminant handrail includes a rod and two fixing seats respectively fixed to two ends of the rod. A fastener is mounted to a bottom of and extends downward from each fixing seat. Two illuminating devices are respectively mounted to the bottoms of the fixing seats. Each illuminating device includes a lamp seat receiving an illuminating unit. The lamp seat of each illuminating device is transparent and includes a top wall and a peripheral wall connected to the top wall. The top wall includes a fixing hole through which one of the fasteners extends. Each illuminating unit includes a lighting unit and a circuit board. Each illuminating unit is mounted between the fixing hole and the peripheral wall of one of the two illuminating devices. The light rays emitted by the illuminating devices transmit through the lamp seats to indicate the position of the handrail.