Invention Grant
- Patent Title: Evaluation method and screening method for sphingosine-1-phosphate 1 (S1P1) receptor agonists
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Application No.: US14912827Application Date: 2014-08-20
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Publication No.: US09885703B2Publication Date: 2018-02-06
- Inventor: Tomohisa Ninomiya , Satoshi Yoshida
- Applicant: MEIJI SEIKA PHARMA CO., LTD.
- Applicant Address: JP Tokyo
- Assignee: MEIJI SEIKA PHARMA CO., LTD.
- Current Assignee: MEIJI SEIKA PHARMA CO., LTD.
- Current Assignee Address: JP Tokyo
- Agency: Sughrue Mion, PLLC
- Priority: JP2013-170383 20130820
- International Application: PCT/JP2014/071737 WO 20140820
- International Announcement: WO2015/025871 WO 20150226
- Main IPC: G01N33/50
- IPC: G01N33/50 ; C07K14/705 ; G01N33/15 ; A61K49/00
Abstract:
It has been found that a main effect (immunosuppressive activity) of an S1P1 receptor agonist correlates with the selectivity for cells expressing a combination of an S1P1 receptor with Gαi2 or Gαi3, and that an adverse effect (cardiotoxicity) of an S1P1 receptor agonist correlates with the selectivity for cells expressing a combination of an S1P1 receptor with Gαi1.
Public/Granted literature
- US20160195513A1 EVALUATION METHOD AND SCREENING METHOD FOR S1P1 RECEPTOR AGONIST Public/Granted day:2016-07-07
Information query
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