The present invention is related to a communication device capable of self-detecting operation status and detecting method thereof. The communication device comprises at least one communication module and a control module. The communication module is capable of self-detecting operation status, so as to generate at least one status information. The control module is allowed to read out the status information of the communication module via a Mobile Industry Processor Interface (MIPI). When the need for the adjustment of operation status of the communication module is diagnosed by the control module, a control signal is generated, and the control signal is transmitted to the communication module via the MIPI, so as to adjust operation status of the communication module. As such, the communication module may be operated under its best status, and also reduce the probability of overheating or abnormal operation.