A computer-implemented method for migrating a buffer used for direct memory access (DMA) may include receiving a request to perform a DMA data transfer between a first partitionable endpoint and a buffer of a first memory in a system having two or more processor chips. Each processor chip may have an associated memory and one or more partitionable endpoints. The buffer from the first memory may be migrated to a second memory based on whether the first memory is local or remote to the first partitionable endpoint, and based on a DMA data transfer activity level. A memory is local to a partitionable endpoint when the memory and the partitionable endpoint are associated with a same processor chip. The DMA data transfer may then be performed.