A mechanism for simultaneous multithreading is provided. Responsive to performing a store instruction for a given thread of threads on a processor core and responsive to the core having ownership of a cache line in a cache, an entry of the store instruction is placed in a given store queue belonging to the given thread. The entry for the store instruction has a starting memory address and an ending memory address on the cache line. The starting memory addresses through ending memory addresses of load queues of the threads are compared on a byte-per-byte basis against the starting through ending memory address of the store instruction. Responsive to one memory address byte in the starting through ending memory addresses in the load queues overlapping with a memory address byte in the starting through ending memory address of the store instruction, the threads having the one memory address byte is flushed.