Disclosed are methods and systems for generating opt-in business leads utilizing targeted advertising campaigns. The method comprises first retrieving an ideal customer profile (ICP), and generating enriched candidates leads that match the ICP. Next, generating test campaigns, receiving feedback information on the test campaigns from candidate leads in test target groups, scoring each test campaign based on received feedback information, and generating a targeted advertising campaign comprising test campaigns with high campaign scores. Opt-in business leads are generated by selecting candidate leads that respond affirmatively to the targeted advertising campaign. The present invention utilizes a closed-loop approach to customize campaign audiences, to optimize targeted advertising campaigns and ICPs, and as a result, to produces high-quality, low-cost, opt-in leads for B2B companies.