A pixel array, a display driving method, a display driving device and a display device are described. The pixel array comprises a plurality of columns of subpixel groups. Each column of subpixel group comprises M×N subpixels, where N is the number of colors of subpixels, and M is an integer equal or greater than 3. Directions in which subpixels of the subpixel groups in odd columns and subpixels of the subpixel groups in even columns are twisted respectively being opposite in a column direction. The pixel array is suitable for application of Pentile technologies under 2D/3D display mode.