The present invention provides a grayscale compensation method, the method includes converting raw image data into a first image data; obtaining a second image data which can be displayed on the display panel according to the first image data in a preset manner, and the second image data for each pixel includes 3-color grayscale data among a red, a green, a blue, and a white grayscale data of the first image data; performing a grayscale compensation on the grayscale data of the second image data according to the first image data and a predetermined rule.