- Patent Title: Methods of using compositions comprising variants and fusions of FGF19 polypeptides for modulating bile acid homeostasis in a subject having nonalcoholic steatohepatitis
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Application No.: US14985137Application Date: 2015-12-30
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Publication No.: US09889178B2Publication Date: 2018-02-13
- Inventor: Lei Ling , Jian Luo
- Applicant: NGM Biopharmaceuticals, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: NGM Biopharmaceuticals, Inc.
- Current Assignee: NGM Biopharmaceuticals, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Jones Day
- Main IPC: A61K38/18
- IPC: A61K38/18 ; C07K14/50 ; G01N33/68 ; G01N33/50
Abstract:
The invention relates to variants and fusions of fibroblast growth factor 19 (FGF19), variants and fusions of fibroblast growth factor 21 (FGF21), fusions of FGF19 and/or FGF21, and variants or fusions of FGF19 and/or FGF21 proteins and peptide sequences (and peptidomimetics), having one or more activities, such as bile acid homeostasis modulating activity, and methods for and uses in treatment of bile acid and other disorders.
Public/Granted literature
- US20160166642A1 USES AND METHODS FOR MODULATING BILE ACID HOMEOSTASIS AND TREATMENT OF BILE ACID DISORDERS AND DISEASES Public/Granted day:2016-06-16
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