Invention Grant
- Patent Title: Selective HDAC6 inhibitors
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Application No.: US15107272Application Date: 2014-12-23
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Publication No.: US09890136B2Publication Date: 2018-02-13
- Inventor: Ronald Breslow , Paul Marks , Adaickapillai Mahendran , Yuanshan Yao
- Applicant: Ronald Breslow , Paul Marks , Adaickapillai Mahendran , Yuanshan Yao
- Applicant Address: US NY New York
- Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK MEMORIAL SLOAN-KETTERING CANCER CENTER
- Current Assignee: THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK MEMORIAL SLOAN-KETTERING CANCER CENTER
- Current Assignee Address: US NY New York
- Agency: Cooper & Dunham LLP
- Agent John P. White
- International Application: PCT/US2014/072234 WO 20141223
- International Announcement: WO2015/100363 WO 20150702
- Main IPC: C07C233/69
- IPC: C07C233/69 ; A61K31/166 ; C07C233/65 ; A61K31/381 ; A61K45/06 ; C07C237/42 ; A61K31/216 ; C07D333/38 ; C07C259/10

Abstract:
The present invention provides a compound having the structure: wherein R1 is halogen, —NR5R6, —NR5—C(═O)—R6, —NH—C(═O)—OR7, —OR7, —NO2, —CN, —SR7, —SO2R7, —CO2R7, CF3, —SOR7, —POR7, —C(═S)R7, —C(═O)—NR5R6, —CH2—C(═O)—NR5R6, —C(═NR5) R6, —P(═O)(OR5)(OR6), —P(OR5)(OR6), —C(═S)R7, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, aryl, heteroaryl, or heterocyclyl, wherein R5, R6, and R7 and are each, independently, H, C1-5 alkyl, C2-5 alkenyl, C2-5 alkynyl, heteroalkyl, hydroxyalkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, C1-5 alkyl-aryl, or C1-5 alkyl-NH-aryl; Ar1 is phenyl or thiophene; wherein when Ar1 is phenyl, then R1 is other than —C(═O)—NR5R6, where one of R5 or R6 is phenyl or quinoline and the other of R5 or R6 is hydroxyalkyl, or where one of R5 or R6 is quinoline and the other of R5 or R6 is H; and wherein when Ar1 is phenyl, then R1 is other than —NR5—C(═O)—R6, where one of R5 is H and R6 is quinoline, or a pharmaceutically acceptable salt thereof.
Public/Granted literature
- US20160347732A1 SELECTIVE HDAC6 INHIBITORS Public/Granted day:2016-12-01
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