Invention Grant
- Patent Title: Retinoic acid receptor antagonists as chaperone-mediated authophagy modulators and uses thereof
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Application No.: US15298280Application Date: 2016-10-20
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Publication No.: US09890143B2Publication Date: 2018-02-13
- Inventor: Ana Maria Cuervo , Evripidis Gavathiotis , Qisheng Xin
- Applicant: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC.
- Applicant Address: US NY Bronx
- Assignee: Albert Einstein College of Medicine, Inc.
- Current Assignee: Albert Einstein College of Medicine, Inc.
- Current Assignee Address: US NY Bronx
- Agency: Amster, Rothstein & Ebenstein LLP
- Main IPC: C07D413/10
- IPC: C07D413/10 ; C07D265/36 ; C07C279/22
Abstract:
Compounds, compositions and methods are provided for selectively activating chaperone-mediated autophagy (CMA), protecting cells from oxidative stress, proteotoxicity and lipotoxicity, and/or antagonizing activity of retinoic acid receptor alpha (RARα) in subjects in need thereof.
Public/Granted literature
- US20170037039A1 RETINOIC ACID RECEPTOR ANTAGONISTS AS CHAPERONE-MEDIATED AUTHOPHAGY MODULATORS AND USES THEREOF Public/Granted day:2017-02-09
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