Invention Grant
- Patent Title: Process for making duocarmycin prodrugs
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Application No.: US15316444Application Date: 2014-06-05
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Publication No.: US09890159B2Publication Date: 2018-02-13
- Inventor: Tijl Huijbregts , Ronald Christiaan Elgersma , Patrick Henry Beusker , Johannes Albertus Frederikus Joosten , Rudy Gerardus Elisabeth Coumans , Henri Johannes Spijker , Wiro Menge , Franciscus Marinus Hendrikus De Groot
- Applicant: SYNTHON BIOPHARMACEUTICALS B.V.
- Applicant Address: NL Nijmegen
- Assignee: Synthon Biopharmaceuticals B.V.
- Current Assignee: Synthon Biopharmaceuticals B.V.
- Current Assignee Address: NL Nijmegen
- Agency: Sterne, Kessler, Goldstein & Fox P.L.L.C.
- International Application: PCT/EP2014/061701 WO 20140605
- International Announcement: WO2015/185142 WO 20151210
- Main IPC: C07D513/02
- IPC: C07D513/02 ; C07D471/04 ; C07D209/60
Abstract:
The present invention relates to a process comprising converting a compound of formula (I) into a compound of formula (II) by reaction with an organolithium reagent, which compound can be further converted into duocarmycin analogs consisting of a DNA-alkylating and a DNA-binding part, and still further into corresponding antibody-drug conjugates.
Public/Granted literature
- US20170145006A1 PROCESS FOR MAKING DUOCARMYCIN PRODRUGS Public/Granted day:2017-05-25
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