Invention Grant
- Patent Title: Peptides based on the transmembrane domain of a toll-like receptor (TLR) for treatment of TLR-mediated diseases
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Application No.: US13811226Application Date: 2011-07-19
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Publication No.: US09890202B2Publication Date: 2018-02-13
- Inventor: Yechiel Shai , Avner Fink , Eliran-Moshe Reuven , Liraz Shmuel-Galia
- Applicant: Yechiel Shai , Avner Fink , Eliran-Moshe Reuven , Liraz Shmuel-Galia
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- International Application: PCT/IL2011/000573 WO 20110719
- International Announcement: WO2012/011100 WO 20120126
- Main IPC: A61K38/16
- IPC: A61K38/16 ; A61K38/10 ; A61K38/00 ; A61K38/04 ; C07K5/00 ; C07K7/00 ; C07K16/00 ; C07K17/00 ; C07K14/705 ; C07K7/08 ; C07K4/00 ; C07K14/00 ; A61K38/03
Abstract:
Peptides are provided that are capable of inhibiting cell activation mediated by a Toll-like receptor (TLR) selected from TLR 1, 2, 4 or 6, said peptide comprising a sequence consisting of, or found within, the sequence of the transmembrane domain of a TLR selected from TLR 1, 2, 4 or 6 and optionally cytoplasmic and extracellular regions flanking the transmembrane domain. These peptides as well as pharmaceutical composition comprising them are useful for the treatment of TLR-mediated disease.
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