Invention Grant
- Patent Title: TAL-Tet1 fusion proteins and methods of use thereof
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Application No.: US13838520Application Date: 2013-03-15
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Publication No.: US09890364B2Publication Date: 2018-02-13
- Inventor: J. Keith Joung , Morgan Maeder , James Angstman
- Applicant: The General Hospital Corporation
- Applicant Address: US MA Boston
- Assignee: The General Hospital Corporation
- Current Assignee: The General Hospital Corporation
- Current Assignee Address: US MA Boston
- Agency: Fish & Richardson P.C.
- Main IPC: A61K38/17
- IPC: A61K38/17 ; C07K14/435 ; C07K19/00 ; C12N15/62 ; A61K48/00 ; A61P35/00 ; A61P25/18 ; A61P9/00 ; C12N9/02
Abstract:
Fusion proteins comprising a DNA binding domain, e.g., a TAL effector repeat array or zinc finger, and a catalytic domain comprising a sequence that catalyzes hydroxylation of methylated cytosines in DNA, and methods of use thereof.
Public/Granted literature
- US20130323220A1 TAL-Tet1 Fusion Proteins and Methods of Use Thereof Public/Granted day:2013-12-05
Information query
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