Invention Grant
- Patent Title: Cytolethal distending toxin subunit B conjugated or fused to Bacillus anthracis toxin lethal factor
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Application No.: US14898248Application Date: 2014-06-19
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Publication No.: US09890369B2Publication Date: 2018-02-13
- Inventor: Christopher H. Bachran , Stephen H. Leppla
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Leydig, Voit & Mayer, Ltd.
- International Application: PCT/US2014/043131 WO 20140619
- International Announcement: WO2014/205187 WO 20141224
- Main IPC: C07K14/32
- IPC: C07K14/32 ; C12N9/22 ; C07K14/285 ; A61K38/16 ; A61K38/46 ; A61K38/48 ; C12N9/54 ; A61K47/64
Abstract:
Disclosed is a protein comprising a cytolethal distending toxin subunit B (CdtB) conjugated or fused to a Bacillus anthracis toxin lethal factor (LF) or a functional portion of LF. Related chimeric molecules, as well as related nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, methods of treating or preventing cancer, and methods of inhibiting the growth of a target cell are also disclosed.
Public/Granted literature
- US20160145590A1 CYTOLETHAL DISTENDING TOXIN SUBUNIT B CONJUGATED OR FUSED TO BACILLUS ANTHRACIS TOXIN LETHAL FACTOR Public/Granted day:2016-05-26
Information query
