Invention Grant
- Patent Title: PRDM14 and FAM19A4, molecular diagnostic markers for HPV-induced invasive cancers and their high-grade precursor lesions
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Application No.: US14434866Application Date: 2013-10-14
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Publication No.: US09890432B2Publication Date: 2018-02-13
- Inventor: Christophorus Joannes Lambertus Maria Meijer , Petrus Josephus Ferdinandus Snijders , Renske Daniëla Maria Steenbergen
- Applicant: SELF-SCREEN B.V.
- Applicant Address: NL Amsterdam
- Assignee: SELF-SCREEN B.V.
- Current Assignee: SELF-SCREEN B.V.
- Current Assignee Address: NL Amsterdam
- Agency: Saul Ewing Arnstein & Lehr LLP
- Agent Gianna Julian-Arnold
- International Application: PCT/NL2013/050729 WO 20131014
- International Announcement: WO2014/058321 WO 20140417
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; C07H21/04 ; C12Q1/70
Abstract:
The invention relates to method for detecting HPV-induced high-grade precancerous lesions and HPV-induced invasive cancers, said method comprising detection of hypermethylation in the PRDM14 and/or FAM19A4 gene in a cell whereby such hypermethylation indicates the presence of HPV-induced precursor lesions with invasive potential and HPV-induced invasive cancers. The invention further comprises the use of the PRDM14 and/or FAM19A4 gene in such a method and a testkit for the detection of PRDM14 and/or FAM19A4 methylation.
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