This disclosure relates generally to data processing, and more particularly, to methods and systems for memory initialization of an integrated circuit. In one embodiment, a method for memory initialization at a circuitry is provided. The method comprises: identifying a portion of the circuitry configured as a memory device; detecting a start of a power-off state for a power domain within the circuitry including the memory device; performing a write operation to write data of a pre-determined pattern to the memory device upon detecting the start of the power-off state; and providing the data stored at the memory device for a reading operation after the power-off state ends.