A microprocessor prepares a fused multiply-accumulate operation of a form ±A*B±C for execution by issuing first and second multiply-accumulate microinstructions to one or more instruction execution units to complete the fused multiply-accumulate operation. The first multiply-accumulate microinstruction causes an unrounded nonredundant result vector to be generated from a first accumulation of a selected one of (a) the partial products of A and B or (b) C with the partial products of A and B. The second multiply-accumulate microinstruction causes performance of a second accumulation of C with the unrounded nonredundant result vector, if the first accumulation did not include C. The second multiply-accumulate microinstruction also causes a final rounded result to be generated from the unrounded nonredundant result vector, wherein the final rounded result is a complete result of the fused multiply-accumulate operation.