Disclosed is a system and method for parallelizing grid search technique facilitating determination of PK-PD parameters. The method may comprise determining number of grids. The method may further comprise creating grid points based upon the number of grids (N) and a number of parameters (p). The method may further comprise distributing the grid points amongst number of threads. The method may further comprise evaluating an objective function value corresponding to each grid point in order to compute an objective function value associated with each of the grid points. Further, the method may comprise identifying a grid point having minimum objective function value. The grid point having the least objective function value may indicate the estimated initial PK-PD parameters.