Circuits and methods are provided for detecting, identifying and/or removing undesired content. According to one embodiment, a processor maintains a page directory and a page table within a system memory for use in connection with translating virtual addresses to physical addresses. Content scanning of a content object is offloaded to a hardware accelerator coupled to the processor by storing content scanning parameters, including the content object and a type of the content object, to the memory using one or more virtual addresses and indicating to the hardware accelerator that the content object is available for content scanning. Responsive thereto, the hardware accelerator: (i) translates the virtual addresses to corresponding physical addresses based on one or more of the page directory and the page table; (ii) accesses scanning parameters based on the physical addresses; (iii) scans the content object for undesirable content by applying multiple signatures; and (iv) returns a result of the content scanning to the processor.