A medicine dispensing system capable of reliably managing the lot of medicines and the expiration period of medicines is provided. A dispensation data preparation section includes a lot change determination section and a data changing section. The lot change determination section determines, based on lot information, whether or not the lot of the medicines to be used may be changed while medicine dispensing apparatuses are in operation. The dispensation data preparation section is provided with an expiration period determination section to determine with reference to the unpacking date, rather than the dispensation date, whether or not medicines are effective for use. This reliably prevents medicines that were taken out of the medicine packing container from being provided to patients after a number of days have passed.