An X-ray imaging guiding system for positioning a region of interest of a patient for X-ray image acquisition includes an X-ray detector arrangement, and graphical positioning information. The graphical positioning information includes a graphical target anatomy representation. The graphical target positioning information is provided in spatial relation with the X-ray detector arrangement. The graphical target anatomy representation indicates a target position of a respective anatomy of the patient for a determined X-ray image acquisition. Further, the graphical positioning information is adaptable in accordance with the determined X-ray image acquisition.