A self-paced, ergonomic feeding bottle with a substantially-straight back sidewall and an “S”-shaped curved front sidewall; where the curved front sidewall comprises two sections: (1) a convex chest section near the top, and (2) a concave handle section near the bottom, comprising a concave crook and a thin waist. The top-heavy bottle has a single plane of symmetry located between the right and left hand sides of the bottle. An anti-vacuum valve can be inserted into a vent hole. Side positioning markers can be used to achieve zero hydrostatic pressure during use. Anti-roll pads are part of the front sidewall.