A control system for remotely configuring a locomotive may include an operational control device located on-board the locomotive, wherein the operational control device may be configured in a run configuration when the locomotive is ready for travel. An on-board controller located on-board the locomotive may be configured to switch the operational control device to the run configuration upon receipt of a configuration command signal. An off-board remote controller interface located remotely from the locomotive may be configured to receive a configuration failure signal, wherein the configuration failure signal may be indicative of the operational control device being in a configuration other than the run configuration. The off-board remote controller interface may selectively send the configuration command signal to the on-board controller to switch the operational control device to the run configuration.