Invention Grant
- Patent Title: Preparation of (R,R)-fenoterol and (R,R)- or (R,S)-fenoterol analogues and their use in treating congestive heart failure
-
Application No.: US15347354Application Date: 2016-11-09
-
Publication No.: US09908841B2Publication Date: 2018-03-06
- Inventor: Irving William Wainer , Weizhong Zhu , Khalid Chakir , Rui-Ping Xiao , Darrell R. Abernethy , Farideh M. Beigi Abhari
- Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: C07C215/60
- IPC: C07C215/60
Abstract:
This disclosure concerns the discovery of (R,R)- and (R,S)-fenoterol analogs which are highly effective at binding β2-adrenergic receptors. Exemplary chemical structures for these analogs are provided. Also provided are pharmaceutical compositions including the disclosed (R,R)-fenoterol and fenoterol analogs, and methods of using such compounds and compositions for the treatment of cardiac disorders such as congestive heart failure and pulmonary disorders such as asthma or chronic obstructive pulmonary disease.
Public/Granted literature
Information query
IPC分类:
